Obesity and adipokines: effects on sympathetic overactivity
Multi-omic, in this context, means the researchers looked simultaneously at the metabolome (the small-molecule fingerprint of cellular activity), the proteome (the protein fingerprint), and the transcriptome (the gene-expression fingerprint), in multiple tissues, in animals and humans treated with GLP-1 agonists versus controls
Albritton KH, Rankin C, Coffin CM, Ratner N, Budd GT, Schuetze SM, et al
Primarily targets skeletal muscle and other metabolically active tissues, where it can affect glucose utilization and energy metabolism in research models
The most common heart-related side effect is a modest increase in resting heart rate, typically 2-4 beats per minute