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Vyndaqel (tafamidis) Disease area(s): Cardiovascular/Rare disease Manufacturer(s): Pfizer 2024 Sales (USD): $5.45 billion Why it sold so well: In 2024, Pfizers Vyndaqel family (including Vyndaqel, Vyndamax and Vynmac) achieved significant sales growth, with global revenues increasing by 60% year-over-year

It also helps with weight loss

Increased plasma GSH led to cysteine depletion, impaired protein synthesis, decreased GPx, and increased GST activities [134]

But Brophy is reluctant to switch medications because Zepbound has also relieved symptoms of longstanding irritable bowel syndrome