Stopping because symptoms improved at week 2 means abandoning the protocol before the structural repair phase has completed
In addition to its peripheral effect, diclofenac and other nonsteroidal antiinflammatory analgesics may have a contraceptive effect (analgesic) in the central nervous system acting on the release of prostaglandins and / or through the neuronal systems which use and catecholamines neurotransmitter serotonin (Pain, 1994, 57: 197-205)
Research involving this compound typically focuses on skin matrix, collagen, and copper peptide signaling research, with attention to receptor activity, cellular signaling, and measurable pathway response in experimental models
We observed evidence of increased lipid peroxidation, a ROS by-product, in both BWS patient hepatocytes as well as in our BWS iPSC-hepatocyte model
If someone has encountered something more concrete on this process, I'm happy to update my knowledge