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In contrast, the combination of PCSK9 neutralizing antibodies and anti-PD1 therapy enhanced CD8+ T cell infiltration and reversed the rise in Treg levels seen with sole anti-PD1 treatment (Wang et al., 2022c)

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In addition, gut microbiota dysbiosis is found to be closely related to neurodegenerative diseases (Shen et al., 2017

Some polymorphisms in genes related to the immunomodulatory response have been identified (69, 74), such as an increase of TNF-857 TT and CT genotypes (p=0.002), and a significant decrease of IFN gamma low producers (A/A) (P=0.04) in ME/CFS patients in respect to controls (74)

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