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Ethics statement This study was approved by the Institutional Review Board (IRB) of Severance Hospital, Seoul, Republic of Korea (IRB number 4-2016-0901) and, when required, written informed consent was obtained from patients at the time of blood sampling

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It has been extensively studied in pre-clinical models across gastrointestinal, musculoskeletal, and neurological research contexts

A smarter, more innovative approach is to choose one priority outcome , then build a simple stack around it