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Native GLP-1 has an extremely short half-life due to rapid degradation by dipeptidyl peptidase-4 (DPP-4), and GLP-1 receptor agonist analogues are engineered with structural modifications to confer resistance to enzymatic cleavage and extend circulating activity in experimental systems

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Other mechanisms of glucagon reduction include increased production of somatostatin, a potent glucagon inhibitor, in the delta cells of the pancreas which can exert a paracrine effect on alpha cells

- May improve libido and sexual health