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The Franz diffusion cell method, which uses ex vivo skin with an intact stratum corneum, can effectively predict in vivo drug penetration (Fig

You won't "crash," but you may notice that your energy levels, skin glow, or recovery times slowly return to where they were before you started

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Practical take For clinicians, this reinforces a more nuanced approach: Match the drug to the patient profile Look beyond average weight loss alone Consider tolerability, adherence, comorbidities, access, and long-term strategy The obesity pipeline is getting deeperand that is good news for patients