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Hydroquinone as a topical depigmenting agent is among the most commonly used therapeutic option in melasma management

Mol Cell Biol 34:832846 Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, Ferrucci L, Gilroy DW, Fasano A, Miller GW, Miller AH, Mantovani A, Weyand CM, Barzilai N, Goronzy JJ, Rando TA, Effros RB, Lucia A, Kleinstreuer N, Slavich GM (2019) Chronic inflammation in the etiology of disease across the life span

When the production of free radicals exceeds the availability of antioxidants, oxidative stress occurs

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Depigmenting Actions The depigmenting ability of Glutathione is well-known