R package, Bio3D was used for dynamic cross-correlation analysis on the trajectory (Grant et al., 2021)

Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Plaque - a deposit of fat, cholesterol, immune cells, fibrin (a clotting protein), and other substances that forms inside arterial walls Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage Test tube - a research experiment performed in a test tube, culture dish, or other artificial environment outside of a living organism

Higher doses (2.0-2.4 mg/week): $250-$400 per month
Fermented foods and probiotics: the guts new best friend Probiotic-rich foods such as yogurt and kimchi act on gut microbiomes, which modulate GLP-1
Signal transduction: the nuclear target