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"Dual receptor pathway activation via GHRH and GHS receptors produces a synergistic somatotropic release that exceeds the potential of single agonists." Peer-reviewed literature on both components is indexable at PubMed at PubMed Secretagogue Blend Collection and related genomic targets cataloged at the NCBI Genomic Database

These disruptions in fuel homeostasis are not clearly related to their primary action of fluid management, raising concerns for patients with metabolic syndrome, in which high blood pressure coexists with obesity, insulin resistance, glucose intolerance and dyslipidemia

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