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Alcohol use

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Biomarkers may yield information relevant to disease outcome on three progressive levels: (i) as measurable endpoints of damage to proteins/amino acids, oxidised lipids, oxidised DNA bases, (ii) as functional markers of, for example, blood flow, platelet aggregation, or cognitive function, and (iii) as endpoints related to specific disease

To the extent that hyperglycemia contributes to renal injury and nephropathy, the antihyperglycemic effects of long-term DPP-4 inhibition might be expected to slow the rate of decline of glomerular function, if this benefit can be sustained for prolonged periods of time [83, 84]