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Auditory activity bidirectionally regulates BDNF and TrkB expression in the AC, as bilateral cochlear ablation induces dynamic changes that initially decrease at 2 weeks but increase at 4 weeks post-ablation, followed by reduction at 6 and 8 weeks, demonstrating that sensory input directly modulates BDNF/TrkB signaling in central auditory structures (Wang et al., 2017)

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