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Rising HbA1c (a marker of long-term blood sugar levels)

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At the proteome level, these species may perturb protein homeostasis, as they contain nucleophilic groups such as aldehydes, ketones and epoxides that can generate advanced lipoxidation end products, by forming adducts with proteins in a process called lipoxidation ( A closely related form of lipotoxicity is associated with the dysregulation of lipid droplets (Olzmann and Carvalho, 2019)