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Thus, experiments with ovariectomized (OVX) rats have shown a reduction in the anti-oxidant activity of superoxide dismutase (SOD) in the hippocampus, a process that contrasts with an increase in the pro-oxidant enzyme monoamine oxidase (MAO) in the same region (Huang and Zhang, 2010)
However, human clinical safety data remain extremely limited
Interestingly, Yuki Sato and coworkers indicated that the antioxidant effect of caffeic acid is more potent than chlorogenic acid, and the latter is metabolized into caffeic acid in the intestine
J Clin Oncol 30:34083416
It has the most complex and largest chemical structure of all vitamins, and it's the only one with a metal ion: cobalt
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