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AMG 133 results in full agonism of human GLP-1R (EC 50 = 24.4 pM) and activated cynomolgus monkey and mouse GLP-1R (EC 50 of 5.7 and 123 pM, respectively)

M., Kramer, M

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In contract, overt hepatic encephalopathy can present with disorientation, obvious personality change, inappropriate behavior, somnolence, stupor, confusion, and coma (106)