liraglutide compared to tirzepatide PSA scatterplot in the trial population (tirzepatide 5, 10 and 15 mg Semaglutide vs Tirzepatide vs Liraglutide

Berberine has the most human trial evidence for supporting GLP-1 activity among natural supplements, though results vary by dose and formulation

It works by binding to GLP-1 receptors in the pancreas, which stimulates the release of insulin in response to food intake

All analyses were performed using Prism 9.3.1 software (GraphPad, San Diego, CA, USA)

People with a history of cardiovascular issues, such as high blood pressure, heart disease, or previous blood clots, should be cautious about using these medications together

In order to obtain experimental results with high clinical relevance, in vivo animal test should be carried out in the near future