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Risk ratios (RR) for nonfatal myocardial infarction estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons
"All the clinical trials that showed these medications working also included education on eating and exercise
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Body Composition Results (12mg Dose, 48 Weeks) Context on lean mass loss: Some lean mass loss (25-30%) is typical with any significant weight loss, including bariatric surgery Lean mass includes muscle, water, bone, and organs, not just muscle The glucagon component may help preserve muscle compared to GLP-1-only drugs Resistance training + adequate protein (1.0-1.2g/kg daily) can minimize muscle loss Visceral Fat Reduction Retatrutide also led to large reductions in visceral adipose tissue (VAT), the fat surrounding internal organs that's linked to metabolic disease
Brazil Market Trends The market in Latin America is led by Brazil, where penetration of private insurance is high, and where there are large volumes of public procurement
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