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Lipid oxidation and oxidative damage to mitochondrial DNA further diminish mitochondrial function, establishing a self-perpetuating vicious cycle to exacerbate mitochondrial dysfunction and oxidative stress [80]

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Theoretically, this immunosuppression state imposed by high-load chronic PE can be seen as a protective factor to reduce the risk of developing autoimmune diseases (Shiu, 2016)

The unapproved product is being evaluated for its use for opioid withdrawal and insomnia