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17 Saxagliptin has been studied both alone and in combination with metformin, pioglitazone, and glyburide

Gastrointestinal Adverse Events GI AEs are the most frequently reported side effects of GLP-1 RAs and, although typically mild, moderate, and transient, they remain the primary reason for treatment discontinuation among individuals with obesity receiving semaglutide [13, 27, 38, 40,41,42,43,44,45,46, 52]

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Front Immunol (2021) 12:667664

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