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Alongside their peroxidase activity, they may also function as molecular chaperones [45] and specific oxidases in signaling pathways through redox relay reactions [46,47]

Moreover, metformins interactions with autophagy in glioma can be further supported by evidence showing that the drug, in combination with other therapies, can alter the tumor microenvironment (34)

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Pretreatment with the active fraction of Rhodiola tangutica (Maxim.) S.H