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6 Conclusion Persistent barriers in solid tumor therapy, including uneven drug penetration, hypoxia- and acidosis-associated resistance and local immunosuppression, reflect structural and functional imbalances in the TME

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Similarly, compounds like pyrvinium pamoate and metformin have shown promise in modulating signaling pathways such as Wnt/-catenin and peroxisome proliferator-activated receptor (PPAR)-, thereby alleviating liver damage (Vangaveti et al