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References Jastreboff AM, Kaplan LM, Frias JP, et al

The activation of GIP receptors by retatrutide promotes glucose dependent insulinotropic polypeptide insulin secretion and insulin release in response to food intake, significantly improving glycemic control

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The absolute bioavailability is approximately 1%, which means 99% of the dose is wasted

Furthermore, GLP-1 RAs seem to have similar safety profile in the IBD population to the one observed in the general population, based on real-world observations