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News provided by Eli Lilly and Company May 21, 2026, 06:45 ET In TRIUMPH-1, participants on 12 mg retatrutide lost an average of 70.3 lbs (28.3%) over 80 weeks with 45.3% of participants achieving 30% weight loss, a level long associated with bariatric surgery Individuals with a baseline BMI 35 who participated in a study extension continued to lose weight, and achieved up to an average of 85.0 lbs (30.3%) weight loss at 104 weeks At the 4 mg dose, reached with only a single escalation step, participants lost an average of 47.2 lbs (19.0%) at 80 weeks with a lower observed discontinuation rate due to adverse events vs

For a specific comparison of these medications, see our Mounjaro vs Ozempic and Zepbound vs Wegovy guides

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However, this effect isn't directly through GCG receptor but through another protein called FGF21, which is secreted by the liver

Scientific Data: A study found that Byetta was associated with more frequent nausea compared to other GLP-1 medications