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TNF- suppression, according to other research, is more likely to cause cutaneous hyperpigmentation than hypo- or depigmentation

274 : 3580935815 Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K and Yodoi J (1997) AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

These are some examples of how OoC technology can represent a next-generation preclinical testing tool, moving beyond conventional toxicology toward precision immuno-oncology, where patient-derived chips could guide therapeutic decisions and dose optimization while reducing reliance on animal models

The Complexity of P53-Mediated Metabolic Regulation in Tumor Suppression