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Although superoxide anion and hydrogen peroxide are not particularly reactive they may synergize with specific factors, eg iron, generating potent free radicals such as hydroxyl radical, which may cause direct injury through alteration of vital cellular macromolecules (DNA, protein or lipids)

I had to begin the whole procedure over again with a red face, sweaty hands and a determination to get it right the second time

10.1016/j.phymed.2024.155560 210 ZoidisE.PappasA

Older blood is associated with increased mortality and adverse events in massively transfused trauma patients: secondary analysis of the PROPPR trial

This reduction in peripheral inflammatory load directly alleviates the burden on the central nervous system