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The colon lining needs both a tight barrier and good micro-blood flow to heal

76 JinJ.PeiG.JiZ.LiuX.YanT.LiW.et al (2024)

FDA statement Semaglutide receptor-engagement model - PeptideFox semaglutide explainer, Chapter 6

The skin is cleaned with an antiseptic wipe at the injection site, usually the upper outer arm, and the intramuscular injection is given with a fine needle in around ten seconds