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Together, these findings outline a causal chain in which obesity-driven systemic adipokine dysregulation activates pro-fibrotic pathways in the skin, although the molecular mechanisms linking adipokines to MMP/TIMP system and extracellular matrix remodeling in HS remain incompletely defined

(Geneva, Switzerland: ICfHoTRfPfH) (2025)

Using the product within this period ensures its effectiveness and safety

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The letter thus provides a clear design specification for compliant AI use: human review with qualified sign-off, rigorous documentation, integration into the quality system and audits