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A randomized controlled trial (NCT04111775) demonstrated that oral charcoal adsorbent AST-120 reduces serum IS concentrations by 58% and decreases the urinary protein-to-creatinine ratio by 29% after 12 weeks, providing evidence that targeting gut-derived uremic toxins offers potential therapeutic benefits for established DN (28, 29)

Kidney failure due to remote organ damage Several risk factors such as genetics, obesity, diabetes, cardiovascular disease, and age can increase the chances of an individual to develop kidney disease, or when already diagnosed, it can gradually drive the progression of the disease (Kazanciolu 2013)

Cell culture and characterization The human BBB co-culture model based on stem cell-derived endothelial cells (hEC) and brain pericytes (PC) were established and characterized by the group of Ceccelli et al