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+ 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase In enzymology, 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (EC 1.3.1.25) is an enzyme that catalyzes the chemical reaction The two substrates of this enzyme are (1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylic acid and oxidised nicotinamide adenine dinucleotide (NAD + )

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Indeed, acetyl-coenzyme A carboxylase (ACC) inhibitor ND-630 slightly recovered cytosolic NADPH levels and viability of glucose-deprived cells (Supplementary Fig

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