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The SEMALEAN study (2025) found a 15% reduction in visceral fat and an average weight loss of 12 kg over six months

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Gene expression Selected genes were examined: (i) genes related to mitochondrial uncoupling ( UCP1, UCP2 ), (ii) the gene encoding transmembrane protein fibronectin type III domain-containing protein 5 precursor of irisin ( FNDC5 ), and (iii) the gene involved in NAD + synthesis ( NAMPT ) (Figure 4)

Although dose titration and use of the lowest effective dose may improve tolerability, long-term outcomes following discontinuation remain inconsistent, and weight regain is common