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They were randomly assigned to Sequence A or Sequence B, where Sequence A started with the GSH intervention followed by the placebo and Sequence B followed the opposite order

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Ding Q, Wang B, Zhan Z, Jangili P, Chen J, Mengji R, et al

How GHK-Cu Works (Mechanism of Action) GHK-Cu functions primarily as: A copper delivery molecule A modulator of gene expression A regulator of extracellular matrix remodelling Copper is an essential cofactor for enzymes involved in: Collagen cross-linking Angiogenesis Antioxidant defense Tissue remodelling GHK-Cu appears to: Increase synthesis of collagen types I and III Stimulate dermal fibroblast activity Modulate matrix metalloproteinases (MMPs) Reduce pro inflammatory signalling in wound models Its effects are local and tissue specific rather than systemic and hormonal

3 The relationship between exercise modalities and PCH 3.1 Single exercise modality-induced PCH 3.1.1 Endurance exercise Endurance exercise is characterized by sustained, moderate-intensity physical activity performed over an extended duration, requiring the integrated function of the cardiovascular and skeletal muscle systems (100)