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GLP-1 receptor agonists operate on several levels

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During early stages of intrauterine life, there is a migration of the precursors of melanocytes, ie melanoblasts from the neural crest to the epidermis

Exenatide was the worlds first clinically used GLP-1RA, developed in 1995 and approved for the treatment of type 2 diabetes mellitus (T2DM) in 2005 due to its proven ability to regulate postprandial glucose levels effectively (DeFronzo et al., 2005