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Moreover, elderly pDCs are less capable of stimulating CD8 + T cells to produce perforin and granzyme, which are crucial for cytotoxic activity, and they are less efficient in promoting IFN- secretion by CD4 + and CD8 + T cells [258]

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For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg

Effects of L-carnitine supplementation on respiratory distress syndrome development and prognosis in premature infants: A single blind randomized controlled trial