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MCP-1 is produced by activated Kupffer cells and infiltrating macrophages and neutrophils

As part of the approval process, it underwent rigorous safety testing and was deemed safe and effective

The Lancet 384:13491357 El Mahdy RN, Nader MA, Helal MG, Abu-Risha SE, Abdelmageed ME (2023) Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-B and TGF-/EGFR signaling pathways

CR-activated cell cycle periodic genes in our study are directly or indirectly involved in tumorigenesis pathways, drive cancer cell proliferation and aggressiveness (RRM2, ACSL3, RBBP8, KMO, FKBP5), drug resistance (ABCC5) and modulate chemosensitivity (FKBP5) (references in Supplementary Table S2A)

Given the heterogeneity of PCOS phenotypes, could GLP-1 RA response predict more favorable long-term cardiovascular outcomes in specific subgroups, beyond just reproductive benefits