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In one embodiment the delivery system is a syringe and needle apparatus that is capable of piercing the tympanic membrane and directly accessing the round window membrane or crista fenestrae cochleae of the auris interna

Common side effects Injection-site reactions: mild redness, tenderness, swelling, occasional bruising - usually resolve within hours Skin flushing / warmth - brief, related to vasodilation Transient fatigue in the first 12 weeks of intensive protocols Mild headache - usually dose-related Higher-dose theoretical concerns Copper accumulation - each 2 mg injection adds roughly 0.03 mg of elemental copper, trivial next to the 0.92.2 mg from a normal diet

Enhancing the cell permeability and metabolic stability of peptidyl drugs by reversible bicyclization

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PMID 21929724