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[14] [15] La tirzepatida se considera particularmente cuando: El control glucmico es inadecuado con metformina u otros agentes orales El paciente tiene obesidad o sobrepeso significativo Se busca minimizar el riesgo de hipoglucemia El paciente no ha logrado objetivos de peso con intervenciones de estilo de vida Contraindicaciones incluyen historia personal o familiar de carcinoma medular de tiroides, sndrome de neoplasia endocrina mltiple tipo 2, reacciones de hipersensibilidad graves al medicamento, y para Zepbound, el embarazo
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