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Peter explores the roles of exercise, sleep, and metabolic health in reducing the risk of cognitive decline and dementia, clarifies common misconceptions about insulin resistance and how to detect it earlier, and examines which supplements may be worth considering versus those that are likely noise
GHK-Cu is an adjunct, not a replacement
M., Culligan, E
The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism
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