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For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145

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As expected, a large number of lipid metabolites changed during liver regeneration, and 12 lipid metabolites showed statistically significant changes during liver regeneration