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We have a full summary of all the major pre-clinical studies and trials below, but as Reta is in Phase III, it's clear that: It showed significant benefit and low safety risk during pre-clinical trials to justify clinical trials

Individuals with kidney failure requiring hemodialysis lose thiamin at an increased rate and are at risk for thiamin deficiency (32)

While it might seem counterintuitive to activate a receptor associated with raising blood sugar, glucagon receptor activation increases energy expenditure through thermogenesis and promotes lipid mobilization

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