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2c was obtained after a sample (from the control group) 5-fold pre-concentration (by solvent evaporation under reduced pressure), thus in the 36 min time range some peaks appear due to bilirubin degradation during sample concentration

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Again, this factor is limited by patient insight (the hardest thing to get across in treating melasma)

It is also crucial to consult with healthcare professionals about the medicines and supplements you are taking to avoid potential interactions and ensure a safe and effective protocol