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The safety profile of semaglutide, in general, has been favorable, but the long-term effects on patients with hypothyroidism remain to be fully elucidated through further research and post-marketing surveillance

For injectable formulations, this can be complex because manufacturers must prove their products work identically to the original subcutaneous semaglutide formulations

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A definitive assessment of its efficacy has yet to be determined

Impurities, synthesis-related fragments, and incorrect amino acid sequences can act as catalysts, accelerating the degradation process once the peptide is reconstituted