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Icariin, delivered via exosomes from mesenchymal stem cells, has been shown to convert pro-inflammatory M1 macrophages in synovial tissue into anti-inflammatory M2 macrophages, at the same time inhibiting glycolysis (190)

Gradual increase by 0.1 mg every 4 weeks

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Mutations in the LPIN2 gene are associated with Majeed syndrome which is characterized by chronic recurrent osteomyelitis, cutaneous inflammation, recurrent fever, and congenital dyserythropoietic anemia