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Similarly, a larger, multi-center trial using Avmacol (Ou et al., 2024) showed mixed results, reporting no significant differences in caregiver ratings for ABC and SRS scores

[DOI] [PubMed] [Google Scholar] 60.Ursini F., Maiorino M., Valente M., Ferri L., Gregolin C

Herein it is hypothesized that excessive intake of folic acid depletes serum holotranscobalamin, thereby decreasing active vitamin B-12 in the circulation and limiting its availability for tissues