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In future trials it will be important to keep track of comorbidities for clinical trial design, either for the purpose of post hoc subgroup analysis or a priori subgroup recruitment, since the neuroathophysiological mechanisms in IC/ BPS patients with different co-morbidities are likely to be different

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A number of researchers have called for the replacement of cyanocobalamin in supplements with other, safer forms of vitamin B12 listed above

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Biol., vol