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Neurons are especially susceptible to hypoxic conditions due to their high energy demand and low glutathione concentrations, which limits their ability to combat oxidative stress 47 , 48

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The calculated activation energies (G in kcal mol -1 ) for the abstraction the C2 proton of 7 to produce the cyanidin enolate ( 8-enolate) were found to be almost identical for the wild-type and the C13S variant, in agreement with their similar dehydratase activity measured experimentally

The current number of AD patients in the U.S