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When administered peripherally, particularly antibody-based GIPR antagonists demonstrate some potential to prevent the development of HFD-induced obesity in rodents (181, 186), but GIPR antagonists show only modest, if any ability to decrease body weight once obesity is already established (181, 183186)

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Recently, a first-in-class unimolecular GLP-1 and amylin receptor agonist, Amycretin, was evaluated in a randomised, placebo-controlled phase 1b/2a trial in adults with overweight or obesity [60]

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