In my world of sports medicine and active adult care, long-term success still depends on protecting muscle, building sustainable eating patterns, and maintaining movement capacity
N Engl J Med 377(3):300301
It enhances insulin secretion from pancreatic -cells in a glucose-dependent manner, whilst simultaneously suppressing glucagon release from -cells ( Notably, GLP-1 appears to be a key messenger of the gut-brain axis
The findings deliver early evidence that semaglutide may offer a dual benefit, targeting obesity and key reproductive challenges associated with the condition, including irregular menstruation and impaired fertility. Clare Thompson, MBBS, BSc, nMRCGP Separately, a review of five randomized controlled trials presented at ENDO 2026 found that GLP-1 drugs, such as semaglutide and liraglutide, do not appear to harm male fertility and may even improve testosterone levels and sperm quality in some men with obesity
However, WW International funded this study, and some of its authors are employees of and shareholders in the company, which increases the risk of bias
