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Mumbais year-round UV intensity, vehicular pollution, and high-humidity environment significantly accelerate oxidative stress and melanin overproduction

In certain non- limiting embodiments, compositions as described herein may be administered orally in a dosage of about 20-40 grams per day, for example, and may be administered once or more than once daily, for example

Improvement with progesterone withdrawal or suppression: Resolution or marked improvement of symptoms after: Stopping progesterone containing medications Suppressing ovulation (and therefore progesterone production) This response strongly supports progesterone hypersensitivity

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PubMed Seiwerth, S., Brcic, L., Vuletic, L