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One reason these drugs are so effective in treating obesity could be that they address the underlying addiction

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(2) their impact on metabolic comorbidities including hyperinsulinemia, dyslipidemia, and hypertension, as well as biomarkers of obesity-related inflammation

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8 Data from a phase 2 trial of 338 adults with obesity without diabetes suggests substantial weight loss benefit with retatrutide, with 26% of participants having a body weight reduction of 30% with the highest dose of retatrutide (12 mg SC once weekly)