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Impact of high-fat diet on liver genes expression profiles in mice model of nonalcoholic fatty liver disease

Safe healing, nutritional recovery and stable eating habits should remain the priority before returning to weight management treatment

Journal of Endocrinology & Metabolism

An oxidation pathway, in which jasmonoyl-isoleucine is oxidized by cytochrome P450 enzymes, mainly CYP94 isoforms, to a 12-hydroxy metabolite and then further via a 12aldehydo intermediate to dicarboxy-jasmonoyl-isoleucine, together with deconjugation by amidohydrolases, is now recognized as a major route for catabolism and deactivation of the hormone, although the hydroxy intermediate can itself cause weak and sustainable expression of certain JA-responsive genes until further oxidation occurs

Under this structure, safety responsibility rests with clinician judgment and pharmacy dispensing compliance, while the platform remains administrative